S-Adenosyl-Methionine(SAMe) helps maintain stable mood and joint function without side effects. In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health.
SAMe is an amino acid derivative normally synthesized in the body that may become depleted with sickness or age.
SAMe is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, and catecholamines and other neurotransmitters.
SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin. SAMe facilitates glutathione usage, which improves the body’s antioxidant defense. It also helps maintain acetylcholine levels which are necessary for cognitive function.
SAMe is used by the body in three important pathways:
- Methylation (contributing methyl groups to activate certain molecules)
- The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)
- Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)
SAMe has multimodal mechanisms of action that are used throughout the body and especially in the liver. In order to perform its detoxification role, the liver continually performs large numbers of complex enzymatic reactions.
SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of glutathione, a critical antioxidant. When liver function is compromised, glutathione is depleted, which leads to free radical damage. In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.
Findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects. Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.
SAMe’s ability to boost brain cell methylation facilitates youthful DNA enzymatic actions which may help account for SAMe’s mood-elevating properties. These enzymatic reactions are required for the healthy conversion of neurotransmitters such as serotonin and dopamine.
S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.
What is Choline?
Choline is a macronutrient that’s important for liver function, normal brain development, nerve function, muscle movement, supporting energy levels and maintaining a healthy metabolism. Choline is present in the form of phosphatidycholine, a compound that makes up the structural component of fat, and thus can be found in different types of foods that naturally contain certain fats. Choline plays a part in several important processes within the body that are carried out hundreds of times, every single day.
What is choline most beneficial for? Choline helps in the process of methylation, which is used to create DNA, for nerve signaling, and for detoxification. It’s also important for the functioning of a key neurotransmitter called acetylcholine, which similarly helps nerves to communicate and muscles to move, acts as an anti-aging neurotransmitter, and performs other basic processes.
Symptoms of a choline deficiency may possibly include:
- low energy levels of fatigue
- memory loss
- cognitive decline
- learning disabilities
- muscle aches
- nerve damage
- mood changes or disorders
People with a condition of the liver called “fatty liver” are at a higher risk for having choline deficiency and experiencing negative symptoms. Fatty liver, also known as fatty liver disease (FLD), is a reversible condition where triglyceride fat accumulates in liver cells. It commonly develops with people who have an excessive alcohol intake, are obese, suffer with diabetes or a form of insulin resistance, and have other diseases that influence fat metabolism.